منابع مشابه
Xenotransplantation: risks, clinical potential, and future prospects.
The reemergence of xenotransplantation as a therapeutic option for the hundreds of thousands of people dying each year of heart, kidney, lung, and liver failure has raised ethical, social, and scientific questions. End-stage organ failure is one of the most important public health problems facing Americans today. Heart failure, for example, kills four times as many people as does HIV infection ...
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Some fully general parametric competing risks models, which allow the underlying (possibly dependent) lifetimes to be modeled as a function of an arbitrary number of covariables, are formulated, and their resulting likelihood function is derived. Under carefully stated regularity conditions, large sample tests of hypotheses concerning the model parameters are obtained for the single point trunc...
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The ethical appropriateness of clinical research depends on protecting participants from excessive risks. Yet no systematic framework has been developed to assess research risks, and as a result, investigators, funders, and review boards rely only on their intuitive judgments. Because intuitive judgments of risk are subject to well-documented cognitive biases, this approach raises concern that ...
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Correspondence: David KC Cooper Thomas E Starzl Transplantation Institute, University of Pittsburgh Medical Center, W1543 Starzl Biomedical Science Tower, 200 Lothrop Street, Pittsburgh, PA 15261, USA Tel +1 412 383 6961 Fax +1 412 624 1172 Email [email protected] Abstract: The transplantation of organs and cells from pigs into humans could overcome the critical and continuing problem of the la...
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n engl j med 357;14 www.nejm.org october 4, 2007 1365 decade. They’ve been able to do so by offering greater speed and efficiency in conducting clinical trials than academic groups can, but questions have been raised about their qualifications, ethics, accountability, and degree of independence from their pharmaceutical-industry clients. Annual CRO-industry revenues have increased from about $7...
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ژورنال
عنوان ژورنال: Journal of the Royal Society of Medicine
سال: 1996
ISSN: 0141-0768,1758-1095
DOI: 10.1177/014107689608900723